When we see an object we can likely understand it. Understanding a process is the first step to figuring out ways to manipulate a process, i.e. to increase its speed or bring it to a standstill. But how do we see things that our eyes cannot, such as a protein drug target? These proteins are 10-100 million times smaller than the smallest animal in the desert. Powerful microscopes cannot achieve the magnification needed to see these structures, so we need to use other techniques. I will introduce other technology such as X-ray diffraction and nuclear magnetic resonance, the scientific high-resolution nephew of MRI's. We leverage these technologies to visualize proteins to understand how to create drug treatments for cancer and diabetes.
Presenter: Wolfgang Peti, Homer C. & Emily Davis Weed Endowed Professor, Chemistry and Biochemistry, University of Arizona